Abetis Tablet

Combination of an ARB and a thiazide diuretic for high blood pressure not adequately controlled by olmesartan alone.

Adults: one tablet once daily — olmesartan 20 mg + HCTZ 12.5 mg, 20/25 or 40/12.5, up to 40/25 mg once daily (maximum).

• Preferably in the morning, with or without food.
• Not recommended in severe kidney impairment (CrCl < 30) or for children.

• Pregnancy
• Severe kidney impairment/anuria, severe liver impairment, biliary obstruction
• Low potassium or sodium, high calcium (resistant), symptomatic gout
• Allergy to olmesartan, thiazides or sulphonamides
• Use with aliskiren in diabetes or kidney impairment

Common: dizziness, headache, tiredness, low blood pressure on standing, raised uric acid, low potassium/sodium, raised blood sugar and lipids.

Less common: muscle cramps, sun sensitivity, impotence.

Rare but serious: sprue-like enteropathy (chronic severe diarrhoea with weight loss), angioedema, kidney failure, acute angle-closure glaucoma, pancreatitis, non-melanoma skin cancer risk with long-term HCTZ.

• Check electrolytes, kidney function, sugar and uric acid periodically.
• Report persistent diarrhoea with weight loss, or sudden eye pain/blurred vision.
• Sun protection and regular skin checks.

Contraindicated in pregnancy. Not recommended while breastfeeding.

• Lithium (toxicity); NSAIDs (reduced effect, kidney injury)
• Potassium supplements/potassium-sparing diuretics
• Digoxin, sotalol (risk if potassium falls); corticosteroids (low potassium)
• Diabetes medicines (dose may change); colesevelam (take 4 hours apart)

Low blood pressure, dehydration, electrolyte loss. Seek medical care.

Store below 30°C.