Cardimet 60 mg Capsule

Anti-anginal metabolic agent used as:

• Add-on treatment of stable angina in adults not adequately controlled by or intolerant of first-line anti-anginal drugs

Adults: modified-release 35 mg twice daily with breakfast and dinner (or immediate-release 20 mg three times daily).

• Moderate kidney impairment (CrCl 30–60) and elderly over 75: 35 mg once daily (in the morning).
• Review after 3 months; stop if no benefit.

• Parkinson's disease, parkinsonian symptoms, tremor, restless legs syndrome and related movement disorders
• Severe kidney impairment (CrCl < 30)
• Allergy to trimetazidine

Common: dizziness, headache, abdominal pain, diarrhoea, indigestion, nausea, rash, weakness.

Serious: parkinsonism (tremor, stiffness, slowness), gait instability, restless legs — usually reversible after stopping; falls in elderly; rarely low platelets, liver problems.

• Stop if movement disorders appear; review by a neurologist if they persist after 4 months off the drug.
• Not for treating an acute angina attack or as initial treatment of unstable angina/heart attack.
• May cause dizziness — caution with driving.

Avoid in pregnancy and breastfeeding.

No major interactions known. Use cautiously with drugs that cause dizziness or falls.

Limited data; supportive care.

Store below 30°C.