Cefuroxime Plus 500 Tablet

Cephalosporin antibiotic combined with a beta-lactamase inhibitor, for infections where resistant bacteria are likely:

• Sinusitis, tonsillitis, pharyngitis, middle-ear infections
• Bronchitis and community-acquired pneumonia
• Urinary tract infections
• Skin and soft-tissue infections

Adults: 250 mg/62.5 mg or 500 mg/125 mg twice daily for 5–10 days, depending on infection.

Children: dose based on cefuroxime content, about 10–15 mg/kg twice daily, as prescribed.

• Take after food for better absorption and less stomach upset.
• Reduce the dose in severe kidney impairment.

• Allergy to cephalosporins, penicillins or clavulanic acid
• Previous jaundice or liver problems with clavulanic acid

Common: diarrhoea, nausea, vomiting, abdominal pain, thrush, headache.

Less common: rash, itching, raised liver enzymes.

Rare: liver inflammation/jaundice, severe allergy, C. difficile colitis, severe skin reactions.

• Penicillin allergy: tell your doctor.
• Liver disease: use with caution (clavulanate can affect the liver).
• Severe diarrhoea: stop and seek medical advice.

Generally considered acceptable when needed. Small amounts in breast milk — usually compatible; watch the baby for diarrhoea or thrush.

• Antacids and acid-reducing drugs (reduce absorption)
• Probenecid (raises levels)
• Warfarin (bleeding risk)
• Oral contraceptives (effect may fall during diarrhoea)

Stomach upset; seizures possible at very high doses in kidney failure.

Store below 25–30°C, dry. Reconstituted suspension: refrigerate and use within 7–10 days.