Clobid 10 mg Tablet

Benzodiazepine used mainly as:

• Add-on treatment for epilepsy (focal and generalised seizures, Lennox–Gastaut syndrome, catamenial/cluster seizures)
• Short-term treatment of severe anxiety (2–4 weeks)

Epilepsy (adults): start 5–10 mg at night; increase gradually to usual 20–30 mg daily (maximum 60 mg) in 1–2 doses.

Children (epilepsy, specialist): over 6 years: start 5 mg daily, maintenance 0.3–1 mg/kg/day; Lennox–Gastaut: weight-based.

Anxiety (adults): 20–30 mg daily in divided doses or at night, for up to 2–4 weeks.

Elderly: 10–20 mg daily.

• Do not stop suddenly — risk of seizures and withdrawal; reduce gradually.
• Tolerance to the antiseizure effect may develop; intermittent use (e.g. cluster or menstrual seizures) is sometimes advised.

• Myasthenia gravis
• Severe respiratory insufficiency, sleep apnoea
• Severe liver impairment
• History of drug or alcohol dependence (relative)
• First trimester of pregnancy (relative)

Common: drowsiness, tiredness, dizziness, unsteadiness, irritability, aggression, mood changes, drooling, constipation, weight gain.

Serious: dependence and withdrawal, breathing depression with opioids or alcohol, severe skin reactions (SJS/TEN), suicidal thoughts, paradoxical agitation.

• Avoid alcohol; do not drive until you know how it affects you.
• Report rash, mood changes or suicidal thoughts.
• Elderly, lung disease: lower doses.

Use in pregnancy only if benefit outweighs risk; newborns may have withdrawal or floppiness if used late. Avoid while breastfeeding.

• Opioids, alcohol, other sedatives, antipsychotics, antihistamines (deep sedation, breathing depression)
• Stiripentol, fluconazole, fluvoxamine, omeprazole (raise levels)
• Carbamazepine, phenytoin (alter levels); clobazam may raise phenytoin/valproate levels
• Hormonal contraceptives (clobazam may reduce their effect at higher doses)

Drowsiness, confusion, slurred speech, slow breathing, coma — especially with alcohol/opioids. Emergency care.

Store below 30°C.