Clorocef 250 mg Capsule

Second-generation oral cephalosporin for:

• Ear infections (otitis media), sinusitis, sore throat and tonsillitis
• Bronchitis and pneumonia
• Urinary tract infections
• Skin and soft-tissue infections

Adults: 250 mg every 8 hours; severe infections 500 mg every 8 hours (maximum 4 g/day).

Extended-release (375/500 mg): twice daily with food.

Children (1 month and over): 20 mg/kg/day in 3 divided doses; severe infections or otitis media 40 mg/kg/day (maximum 1 g/day).

• Guide: under 1 year 62.5 mg, 1–5 years 125 mg, over 5 years 250 mg — three times daily.
• Usually 7–10 days (10 days for strep throat).

• Allergy to cephalosporins
• Severe immediate allergy to penicillins

Common: diarrhoea, nausea, rash, itching.

Less common: vomiting, thrush, headache.

Rare but serious: serum-sickness-like reaction (rash, joint pain and fever, mainly in children, after several days), anaphylaxis, severe skin reactions, C. difficile colitis, liver or kidney inflammation, low blood counts.

• Ask about penicillin/cephalosporin allergy.
• Stop and report rash with joint pain or fever.
• Severe kidney impairment: monitor.

Considered safe in pregnancy and breastfeeding when needed.

• Probenecid (raises levels)
• Warfarin (increased effect)
• Antacids with magnesium/aluminium (reduce absorption of extended-release form — take 1 hour apart)

Nausea, vomiting, diarrhoea. Supportive care.

Store below 30°C, dry. Reconstituted suspension: keep in a fridge and use within 14 days.