Empastar 25 mg Tablet

SGLT2 inhibitor for:

• Type 2 diabetes in adults (with diet and exercise, alone or with other medicines)
• Reducing the risk of cardiovascular death in type 2 diabetes with heart disease
• Heart failure (reduced or preserved ejection fraction), with or without diabetes
• Chronic kidney disease (slowing progression), with or without diabetes

Adults: 10 mg once daily in the morning, with or without food.

• Type 2 diabetes: may be increased to 25 mg once daily if more sugar control is needed (and eGFR is 60 or above).
• Heart failure and chronic kidney disease: 10 mg once daily.

Kidney function: for blood-sugar lowering, start only if eGFR ≥ 20–30 (sugar effect is weaker at low eGFR); for heart and kidney protection 10 mg may be used down to eGFR 20.

• Not for children under 10 years; type 1 diabetes not approved.

• Allergy to empagliflozin
• Type 1 diabetes or diabetic ketoacidosis
• Dialysis

Common: genital fungal infections (itching, discharge — especially women and uncircumcised men), urinary tract infections, passing more urine, thirst, raised cholesterol.

Less common: dehydration, dizziness, low blood pressure (elderly, on diuretics), low blood sugar with insulin or sulphonylureas, itching.

Rare but serious: ketoacidosis even with near-normal blood sugar (nausea, vomiting, stomach pain, fast breathing — emergency), Fournier's gangrene (painful swelling around the genitals with fever), severe kidney infection.

• Stop 3 days before planned surgery, and during acute illness, fasting, vomiting or diarrhoea (sick-day rules).
• Drink enough fluids; elderly and people on diuretics may become dehydrated.
• Keep the genital area clean and dry.
• Check ketones if unwell, even if sugar is normal.

Not recommended in pregnancy (especially 2nd and 3rd trimesters) or while breastfeeding.

• Loop and thiazide diuretics (dehydration, low blood pressure)
• Insulin, sulphonylureas (low blood sugar — their dose may need lowering)
• Lithium (levels may fall — monitor)
• Urine glucose tests are positive while taking it (expected)

Increased urine output and dehydration; low sugar if combined with other diabetes drugs. Supportive care.

Store below 30°C.