Endamycin 300 mg Capsule

Lincosamide antibiotic for:

• Serious skin and soft-tissue infections, abscesses
• Bone and joint infections
• Dental infections
• Chest infections, lung abscess, aspiration pneumonia
• Pelvic and abdominal infections (with other antibiotics)
• Topical gel/lotion: acne; vaginal cream: bacterial vaginosis
• Alternative for people allergic to penicillin

Adults (oral): 150–300 mg every 6 hours; severe infections up to 450 mg every 6 hours.

Injection: 600 mg–2.7 g daily in 2–4 divided doses (hospital).

Children (oral): 3–6 mg/kg every 6 hours (8–25 mg/kg/day).

Acne gel/lotion 1%: apply a thin layer to affected skin twice daily.

Vaginal cream 2%: one applicator at bedtime for 3–7 nights.

• Take capsules with a full glass of water to avoid throat irritation.

• Allergy to clindamycin or lincomycin
• History of antibiotic-associated colitis

Common: diarrhoea, nausea, stomach pain, rash; topical: dryness, peeling, redness.

Rare but serious: C. difficile colitis (severe or bloody diarrhoea — may occur even weeks after stopping), severe skin reactions, liver problems, low blood counts, oesophageal ulcer.

• Stop and seek help if severe or persistent diarrhoea develops; do not take anti-diarrhoeal medicines.
• Elderly and people with bowel disease are at higher risk of colitis.
• Liver disease: monitor with long courses.
• Vaginal cream may weaken latex condoms.

Can be used in pregnancy when needed. Passes into breast milk; watch the baby for diarrhoea or thrush.

• Erythromycin (antagonism — avoid together)
• Neuromuscular blockers (enhanced effect in surgery)
• Rifampicin (reduces levels)
• Warfarin (monitor INR)

Gastrointestinal upset. Supportive care.

Store below 30°C.