Extracef 1 gm Injection

First-generation cephalosporin antibiotic used for infections caused by sensitive bacteria:

• Throat, ear and sinus infections
• Chest infections (bronchitis, pneumonia)
• Urinary tract infections
• Skin, soft-tissue and bone infections
• Injection: surgical prophylaxis and more serious infections

Adults (oral): 250–500 mg every 6 hours, or 500 mg–1 g every 12 hours; up to 4 g daily in severe infections.

Adults (injection, IM/IV): 2–4 g daily in 4 divided doses; up to 8 g daily in severe infections.

Children (oral): 25–50 mg/kg/day in 2–4 divided doses (up to 100 mg/kg/day for ear infections), as prescribed.

• Can be taken with or without food.
• Reduce the dose in kidney disease.

• Allergy to cephradine or other cephalosporins
• History of severe (anaphylactic) reaction to penicillins

Common: nausea, diarrhoea, abdominal discomfort.

Less common: rash, itching, thrush (oral or vaginal), headache, dizziness.

Rare: severe allergic reaction, C. difficile colitis (severe diarrhoea), blood disorders, raised liver enzymes. Pain at the injection site with IM use.

• About 10% of people allergic to penicillin may also react to cephalosporins.
• Use a lower dose in kidney impairment.
• Can give a false-positive urine glucose test (copper-reduction method).

Generally considered safe in pregnancy when needed. Passes into breast milk in small amounts — usually acceptable; watch the baby for diarrhoea or thrush.

• Probenecid (increases cephradine levels)
• Loop diuretics (e.g. furosemide) and aminoglycosides — possible increased kidney toxicity
• Warfarin (may increase bleeding risk)

Nausea, vomiting, stomach pain and diarrhoea; seizures are possible at very high doses, especially in kidney failure.

Store below 30°C, dry and away from light. Reconstituted suspension: refrigerate and use within 7 days. Use reconstituted injection promptly.