Exzilor Tablet

Combination of a low-dose antipsychotic (flupentixol) and a tricyclic antidepressant (melitracen) for:

• Mild to moderate depression and anxiety
• Psychosomatic complaints associated with anxiety/depression (e.g. functional dyspepsia, tension headache)
• Short-term use as directed by a doctor

Adults: 1 tablet (flupentixol 0.5 mg + melitracen 10 mg) in the morning, or 2 tablets daily (morning and noon).

• Severe cases: up to 2 tablets in the morning on medical advice.
• Elderly: 1 tablet in the morning.
• Maintenance: usually 1 tablet in the morning.
• Avoid evening doses (may disturb sleep).
• Not for children and adolescents under 18.
• Reduce gradually rather than stopping suddenly.

• Recent heart attack, heart block, arrhythmias, uncontrolled heart disease
• Narrow-angle glaucoma
• Use with MAO inhibitors (or within 14 days)
• Severe states of excitement or agitation, coma, CNS depression
• Phaeochromocytoma, blood disorders

Common: restlessness, insomnia (if taken late), dry mouth, constipation, dizziness, tremor, blurred vision.

Less common: fast heartbeat, weight gain, urinary difficulty, sweating, sexual dysfunction.

Rare but serious: movement disorders (tardive dyskinesia with long use), irregular heartbeat (QT prolongation), seizures, low blood counts, neuroleptic malignant syndrome, jaundice.

• Intended for short-term use; regular review needed.
• Heart disease, epilepsy, prostate enlargement, liver disease, thyroid disease: caution.
• Watch for worsening mood or suicidal thoughts.
• May affect driving.

Avoid in pregnancy and breastfeeding unless the doctor considers it necessary.

• MAO inhibitors (contraindicated)
• Alcohol, sedatives (more sedation)
• Other antidepressants, tramadol (serotonin syndrome, seizures)
• Drugs prolonging QT (amiodarone, macrolides, some antihistamines)
• Levodopa (reduced effect); anticholinergics (more side effects)

Drowsiness, convulsions, irregular heartbeat, low blood pressure, coma — dangerous; emergency treatment.

Store below 30°C, protected from light.