Itrader 100 mg Capsule

Triazole antifungal for:

• Ringworm of the skin (tinea corporis, cruris, pedis, manuum) — extensive or resistant cases
• Pityriasis versicolor
• Fungal nail infections (onychomycosis)
• Oral and vaginal candidiasis
• Systemic fungal infections: aspergillosis, histoplasmosis, sporotrichosis, blastomycosis (specialist)

Capsules (adults) — take with a full meal:

• Tinea corporis/cruris: 100 mg daily for 15 days, or 200 mg daily for 7 days.
• Tinea pedis/manuum: 100 mg daily for 30 days, or 200 mg twice daily for 7 days.
• Pityriasis versicolor: 200 mg daily for 7 days.
• Vaginal candidiasis: 200 mg twice daily for 1 day.
• Oral thrush: 100 mg daily for 15 days.
• Nails (pulse therapy): 200 mg twice daily for 1 week each month — 2 pulses for fingernails, 3 for toenails (or 200 mg daily for 3 months).
• Systemic infections: 200 mg once or twice daily (specialist).

Oral solution: take on an empty stomach (not interchangeable with capsules mg-for-mg).

• Not routinely for children.

• Heart failure or history of it (except life-threatening infections)
• Pregnancy (for non-life-threatening infections)
• Use with: simvastatin, lovastatin, midazolam (oral), triazolam, pimozide, quinidine, dofetilide, ergot alkaloids, ivabradine, ranolazine, colchicine (in kidney/liver impairment), some others
• Allergy to azoles

Common: nausea, stomach pain, diarrhoea, headache, rash, indigestion.

Less common: dizziness, raised liver enzymes, menstrual changes, swelling, low potassium.

Rare but serious: heart failure (breathlessness, ankle swelling, rapid weight gain), liver failure (jaundice, dark urine), severe skin reactions, nerve damage (tingling), hearing loss, QT prolongation.

• Liver function tests during courses over 1 month, or in liver disease.
• Stop and seek help with signs of heart failure or liver problems.
• Capsules need stomach acid — take with food or an acidic drink (cola) if taking acid-reducers.
• Women of child-bearing age: use contraception during treatment and until the next period after stopping.

Contraindicated in pregnancy except for life-threatening infections. Avoid while breastfeeding.

Many serious interactions (strong CYP3A4 inhibitor):

• Contraindicated drugs listed above
• Warfarin, ciclosporin, tacrolimus, digoxin, calcium-channel blockers, some anticancer drugs, budesonide/fluticasone (raised levels)
• Rifampicin, phenytoin, carbamazepine (greatly reduce itraconazole — avoid)
• PPIs, H2 blockers, antacids (reduce capsule absorption)

Limited data; supportive care.

Store below 30°C, dry, protected from light.