Jafa 8 mg Tablet

Anti-sickness medicine (5-HT3 antagonist) for:

• Nausea and vomiting caused by cancer chemotherapy and radiotherapy
• Prevention and treatment of nausea and vomiting after surgery
• Severe vomiting in gastroenteritis in children (single dose, on medical advice)

Chemotherapy (adults): 8 mg 1–2 hours before treatment, then 8 mg every 12 hours for up to 5 days (higher IV doses for highly emetogenic regimens, maximum 16 mg per single IV dose).

After surgery (adults): 4 mg IV/IM at induction, or 16 mg orally 1 hour before anaesthesia.

Children: 0.1–0.15 mg/kg (max 4 mg) IV, or oral dose by body surface area/weight, as prescribed.

Severe liver disease: maximum 8 mg/day.

• Orally disintegrating tablets: place on the tongue, they dissolve without water.

• Allergy to ondansetron or other 5-HT3 antagonists
• Use with apomorphine (severe low blood pressure)
• Congenital long-QT syndrome

Common: headache, constipation, feeling warm or flushed, tiredness, injection-site reactions.

Less common: hiccups, dizziness, low blood pressure, raised liver enzymes.

Rare but serious: irregular heartbeat (QT prolongation), chest pain, seizures, involuntary movements, temporary blurred vision, serotonin syndrome (with SSRIs), severe allergy.

• Correct low potassium or magnesium before use; caution with heart-rhythm problems.
• May mask bowel obstruction after abdominal surgery.
• Serotonin syndrome risk with antidepressants (agitation, fever, muscle twitching).

Avoid in the first trimester unless clearly needed (small reported increase in cleft palate). Probably passes into milk; use if benefits outweigh risks.

• Apomorphine (contraindicated)
• QT-prolonging drugs (some antiarrhythmics, antipsychotics, macrolides, quinolones)
• SSRIs, SNRIs, tramadol (serotonin syndrome)
• Carbamazepine, phenytoin, rifampicin (reduce effect)
• Tramadol (reduced pain relief)

Visual disturbance, constipation, low blood pressure, fainting, QT prolongation. Supportive care with ECG monitoring.

Store below 30°C, protect from light. Do not freeze injection.