Lanso 30 mg Capsule

Proton-pump inhibitor for:

• Gastro-oesophageal reflux disease (GERD), heartburn, erosive oesophagitis
• Duodenal and gastric ulcers; NSAID-associated ulcers (treatment and prevention)
• H. pylori eradication (with antibiotics)
• Zollinger–Ellison syndrome

Adults:

• GERD/oesophagitis: 30 mg once daily for 4–8 weeks; maintenance 15–30 mg daily.
• Heartburn (non-erosive): 15–30 mg daily for up to 4 weeks.
• Duodenal ulcer: 30 mg daily for 2–4 weeks; gastric ulcer 30 mg daily for 4–8 weeks.
• NSAID ulcer prevention: 15–30 mg daily.
• H. pylori: 30 mg twice daily with two antibiotics for 7–14 days.

Children (specialist): under 30 kg 15 mg daily; over 30 kg 30 mg daily.

• Take in the morning 30 minutes before food; swallow capsules whole (orodispersible tablets dissolve on the tongue).

• Allergy to lansoprazole or other PPIs
• Use with atazanavir or rilpivirine

Common: headache, diarrhoea, nausea, abdominal pain, constipation, wind, dizziness, tiredness.

Long-term: low magnesium, vitamin B12 deficiency, fractures, C. difficile diarrhoea, stomach polyps.

Rare: microscopic colitis (chronic watery diarrhoea), kidney inflammation, severe skin reactions, liver problems, low blood counts.

• Exclude stomach cancer if alarm symptoms are present.
• Lowest effective dose for the shortest time; review long-term use.
• Severe liver disease: dose reduction.

Can be used in pregnancy when needed (omeprazole has the most data). Small amounts in milk; generally considered acceptable while breastfeeding.

• Atazanavir, rilpivirine (avoid)
• Ketoconazole, itraconazole, iron (reduced absorption)
• Tacrolimus, methotrexate (high dose), theophylline (levels may change)
• Antacids, sucralfate (take lansoprazole 1 hour before)

Limited experience; supportive care.

Store below 30°C, dry.