Lopo 25 mg Tablet

Angiotensin II receptor blocker (ARB) for:

• High blood pressure
• Kidney protection in type 2 diabetes with protein in the urine (diabetic nephropathy)
• Heart failure when ACE inhibitors are not tolerated
• Reducing stroke risk in hypertension with left ventricular hypertrophy

High blood pressure: 50 mg once daily; may increase to 100 mg once daily (25 mg starting dose in low fluid volume or liver impairment).

Diabetic nephropathy: 50 mg once daily, increased to 100 mg.

Heart failure: start 12.5 mg once daily, increase gradually to 50–150 mg once daily.

Children (6–18 years, over 20 kg): 0.7 mg/kg once daily (max 50 mg), as prescribed.

• Take at the same time each day, with or without food.
• Full effect on blood pressure in 3–6 weeks; keep taking even if you feel well.

• Allergy to losartan
• Pregnancy (2nd and 3rd trimesters — and avoid in the 1st)
• Severe liver impairment
• Use with aliskiren in diabetes or kidney impairment

Common: dizziness, low blood pressure (especially when standing), tiredness, high potassium, raised kidney values, low blood sugar (in diabetes).

Less common: headache, cough (less than ACE inhibitors), stomach upset, back pain.

Rare: angioedema (swelling of face, lips, throat), liver problems, low platelets, muscle pain.

• Check kidney function and potassium after starting and dose changes.
• Correct dehydration/salt depletion first (risk of low BP).
• Kidney artery narrowing: risk of kidney failure.
• Stop and seek urgent help if face/lip/throat swelling occurs.

Do not use in pregnancy — can harm the baby's kidneys and skull. Switch before a planned pregnancy. Not recommended while breastfeeding (other medicines preferred).

• Potassium supplements, salt substitutes, spironolactone, amiloride, trimethoprim (high potassium)
• NSAIDs (reduced effect, kidney risk)
• Lithium (toxicity)
• ACE inhibitors or aliskiren (dual blockade — avoid)
• Other blood-pressure medicines (additive effect)

Low blood pressure, fast or slow heartbeat. Lie down with legs raised; seek medical care.

Store below 30°C, protected from moisture.