Naprozol 500 Tablet

Combination of an NSAID painkiller (naproxen) and a stomach protector (esomeprazole) for:

• Symptoms of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis
• In patients at risk of developing NSAID-related stomach ulcers

Adults: 1 tablet (375 mg/20 mg or 500 mg/20 mg) twice daily.

• Take at least 30 minutes before meals; swallow whole — do not split, chew or crush.
• Not suitable for acute pain (slow onset) or for children.
• Use the lowest effective dose for the shortest time.

• Allergy to naproxen, esomeprazole, aspirin, other NSAIDs or PPIs
• Severe heart failure, active GI bleeding or ulcer
• Severe liver or kidney impairment
• Last 3 months of pregnancy
• Use with atazanavir or nelfinavir

Common: indigestion, stomach pain, diarrhoea, nausea, wind, headache, dizziness, fluid retention.

Serious (rare): GI bleeding despite protection, heart attack/stroke, kidney damage, severe skin reactions, liver problems; long-term PPI effects (low magnesium, B12 deficiency, fractures).

• Caution in high blood pressure, heart disease, kidney or liver disease, asthma, the elderly.
• Does not protect the lower bowel from NSAID damage.

Avoid in the first 6 months unless advised; contraindicated in the last 3 months. Avoid while breastfeeding.

• Anticoagulants, antiplatelets, SSRIs (bleeding)
• ACE inhibitors, ARBs, diuretics (kidney risk)
• Lithium, methotrexate (toxicity)
• Clopidogrel (reduced effect with esomeprazole)
• Atazanavir, ketoconazole (absorption affected)

Drowsiness, stomach pain, nausea, vomiting; bleeding or kidney failure possible. Seek medical care.

Store below 30°C in the original container.