Neopril 5 mg Tablet

ACE inhibitor for:

• High blood pressure
• Heart failure
• Within 24 hours of a heart attack (in stable patients)
• Diabetic kidney disease (protein in urine)

Hypertension: start 10 mg once daily (2.5–5 mg if on diuretics, kidney impairment or elderly); usual 20 mg; maximum 80 mg daily.

Heart failure: start 2.5 mg once daily, increase gradually to 5–35 mg daily.

After heart attack: 5 mg within 24 hours, 5 mg after 24 hours, 10 mg after 48 hours, then 10 mg daily for 6 weeks (if BP allows).

Children 6–16 (hypertension): 0.07 mg/kg once daily (up to 5 mg) initially.

• Same time daily, with or without food.

• History of angioedema (with ACE inhibitors or hereditary)
• Pregnancy
• Use with sacubitril/valsartan (within 36 hours), or aliskiren in diabetes/kidney impairment
• Bilateral renal artery stenosis

Common: dry cough, dizziness, headache, low blood pressure, raised potassium, raised creatinine, tiredness, diarrhoea.

Less common: rash, taste changes, palpitations.

Rare but serious: angioedema (emergency), kidney failure, liver problems, low blood counts, pancreatitis.

• Check kidney function and potassium before and 1–2 weeks after starting or dose changes.
• Avoid dehydration; pause during severe vomiting/diarrhoea (sick-day rules).
• Black patients may respond less and have higher angioedema risk.

Contraindicated in pregnancy. Not recommended while breastfeeding (enalapril/captopril preferred if needed).

• Potassium supplements, salt substitutes, spironolactone, trimethoprim (high potassium)
• NSAIDs (reduced effect, kidney injury)
• Lithium (toxicity)
• ARBs, aliskiren, sacubitril (avoid)
• Diuretics (first-dose low BP); insulin/sulphonylureas (hypoglycaemia)

Low blood pressure, kidney failure, high potassium. Emergency care; haemodialysis removes it.

Store below 30°C.