Neozine 1 % Cream

Topical antibacterial cream (1%) for:

• Prevention and treatment of infection in burns (second- and third-degree)
• Leg ulcers, pressure sores, infected skin wounds and graft sites

Burns: after cleaning, apply a layer about 3–5 mm thick with a sterile gloved hand or spatula once or twice daily (more often if the wound has a lot of discharge); cover with a dressing if needed.

Leg ulcers/wounds: apply to the ulcer surface at least 3 times a week.

• Clean off the old cream before reapplying.
• Continue until healing or the area is ready for grafting.

• Allergy to sulphonamides or silver
• Pregnancy near term, premature babies and newborns under 2 months (risk of kernicterus)

Common: burning, itching, rash at the site; temporary grey/black skin discolouration (argyria) with prolonged use on large areas.

Systemic (large burns): low white cell count (usually temporary), allergic reactions, rarely severe skin reactions (SJS), kidney problems, haemolysis in G6PD deficiency.

• Large burns: monitor blood counts and kidney function.
• G6PD deficiency, kidney or liver impairment: caution.
• Do not use for prolonged periods on the face (staining).
• Fungal overgrowth may occur in the wound.

Avoid near term (last weeks of pregnancy); use earlier only if needed. Avoid in breastfeeding of premature or jaundiced babies.

• Topical enzymatic debriding agents (may be inactivated)
• If absorbed in large amounts: sulphonylureas, phenytoin, warfarin (enhanced effects)

Not expected with normal use; with very large burns, sulphonamide toxicity possible — monitor.

Store below 25–30°C; keep the jar closed and protected from light (cream darkens with light).