Noburn 5 mg/5 ml Suspension

Anti-sickness medicine that also speeds stomach emptying:

• Nausea and vomiting (short-term)
• Bloating, fullness and discomfort after meals (functional dyspepsia), when advised by a doctor
• Nausea caused by some medicines (e.g. levodopa in Parkinson's disease)

Adults and adolescents (12 years and over, 35 kg or more): 10 mg up to three times daily; maximum 30 mg per day.

Children under 35 kg: 0.25 mg/kg up to three times daily (maximum 0.75 mg/kg/day), only if prescribed.

• Take 15–30 minutes before meals.
• Use for the shortest time possible — normally not more than 7 days.

• Allergy to domperidone
• Moderate or severe liver impairment
• Known heart-rhythm problems (QT prolongation), heart failure, low potassium or magnesium
• Use with strong CYP3A4 inhibitors (ketoconazole, itraconazole, clarithromycin, erythromycin, ritonavir) or QT-prolonging drugs
• Prolactin-secreting pituitary tumour
• Bowel obstruction, perforation or bleeding

Common: dry mouth.

Less common: headache, drowsiness, diarrhoea, anxiety, itching, breast swelling or tenderness, milk discharge, irregular periods.

Rare but serious: irregular heartbeat or sudden cardiac death (risk higher above 30 mg/day or over 60 years), involuntary movements, seizures.

• Do not exceed the dose; stop and seek help if you feel palpitations or faintness.
• Higher heart risk in people over 60 and with other heart medicines.
• Kidney impairment: reduce dosing frequency.

Avoid in pregnancy unless clearly needed. Passes into breast milk in small amounts; avoid unless the benefit outweighs the risk (especially if mother or baby has heart risk).

• Ketoconazole, itraconazole, clarithromycin, erythromycin, HIV protease inhibitors (raise domperidone and heart risk)
• Other QT-prolonging drugs (amiodarone, some antipsychotics, antidepressants, ondansetron)
• Anticholinergic drugs such as hyoscine (reduce its effect)

Drowsiness, confusion, involuntary movements (especially children), heart-rhythm changes. Seek medical care; ECG monitoring.

Store below 30°C, protected from light.