Nogal 150 mg Tablet

Antifungal medicine for:

• Vaginal thrush (vaginal candidiasis) and fungal balanitis
• Oral and throat thrush, oesophageal candidiasis
• Fungal skin and nail infections (tinea, pityriasis versicolor) when topical treatment is not enough
• Systemic candida infections and cryptococcal meningitis (in hospital)
• Prevention of fungal infections in people with weak immunity

Vaginal thrush / balanitis: 150 mg single dose.

Oral thrush: 50–100 mg once daily for 7–14 days. Oesophageal candidiasis: 200 mg on day 1, then 100–200 mg daily for 14–30 days.

Skin infections (tinea): 150 mg once weekly or 50 mg daily for 2–4 weeks (up to 6 weeks). Pityriasis versicolor: 300 mg once weekly for 2 weeks (or 50 mg daily 2–4 weeks).

Nail infections: 150 mg once weekly for 6–12 months.

Serious infections: 400–800 mg daily as directed.

Children: 3–12 mg/kg once daily depending on infection, as prescribed.

• Can be taken with or without food. Reduce the dose in kidney impairment (repeated dosing).

• Allergy to fluconazole or other azole antifungals
• Use with terfenadine (at high fluconazole doses), cisapride, astemizole, pimozide, quinidine, erythromycin (QT risk)

Common: headache, abdominal pain, nausea, diarrhoea, vomiting, rash, raised liver enzymes.

Less common: dizziness, taste change, indigestion, tiredness.

Rare but serious: liver damage, QT prolongation/irregular heartbeat, severe skin reactions, severe allergy, low potassium.

• Use with caution in liver disease and heart rhythm problems.
• Long courses: liver function tests.
• Stop and seek help if rash with blisters or yellowing of skin/eyes occurs.

Avoid in pregnancy, especially high or long-term doses (birth defect risk); use topical treatments for vaginal thrush in pregnancy. Single 150 mg dose is generally acceptable while breastfeeding; avoid high doses.

• QT-prolonging drugs (erythromycin, pimozide, quinidine, some antipsychotics)
• Warfarin (bleeding risk), sulphonylureas (low blood sugar)
• Statins (simvastatin, atorvastatin — muscle damage risk)
• Phenytoin, ciclosporin, tacrolimus, midazolam, amitriptyline (levels rise)
• Rifampicin (lowers fluconazole)

Hallucinations and paranoid behaviour have been reported. Seek medical care; dialysis can help.

Store below 30°C. Reconstituted suspension: use within 14 days.