Pantex 20 mg Tablet

Proton-pump inhibitor for:

• Gastro-oesophageal reflux disease (GERD), heartburn, reflux oesophagitis
• Gastric and duodenal ulcers
• H. pylori eradication (with antibiotics)
• Prevention of NSAID-associated ulcers
• Zollinger–Ellison syndrome
• Injection: bleeding ulcers, stress ulcer prevention, when oral use is not possible

Adults:

• Reflux oesophagitis: 40 mg once daily for 4–8 weeks (up to 80 mg); maintenance 20–40 mg daily.
• Heartburn: 20 mg once daily.
• Ulcers: 40 mg once daily for 2–8 weeks.
• H. pylori: 40 mg twice daily with two antibiotics for 7–14 days.
• NSAID ulcer prevention: 20 mg once daily.

IV: 40 mg once daily (80 mg bolus then infusion for bleeding ulcers in hospital).

Children (12 years and over): 20–40 mg once daily for reflux.

• Take 1 hour before a meal; swallow whole (do not crush or chew).

• Allergy to pantoprazole or other PPIs
• Use with atazanavir or nelfinavir

Common: headache, diarrhoea, nausea, abdominal pain, wind, constipation, benign stomach polyps.

Less common: dizziness, rash, itching, sleep problems, raised liver enzymes.

Long-term: low magnesium, vitamin B12 deficiency, fractures, gut infections.

Rare: severe skin reactions, kidney inflammation, liver injury, low sodium.

• Exclude cancer if alarm symptoms are present (weight loss, vomiting blood, black stools, difficulty swallowing).
• Use the lowest dose for the shortest time; long-term users should have magnesium checked.
• Severe liver disease: maximum 20 mg/day.

Limited data; use in pregnancy only if needed. Small amounts in breast milk — use if benefits outweigh risks.

• Atazanavir, nelfinavir, rilpivirine (reduced absorption — avoid)
• Ketoconazole, itraconazole, iron (reduced absorption)
• Methotrexate high dose (levels rise)
• Warfarin (monitor INR)

No specific symptoms known; supportive treatment.

Store below 30°C, dry, in the original pack.