Pristibion Tablet

Neurotropic B vitamins (B1, B6, B12) for:

• Nerve pain and tingling/numbness (peripheral neuropathy), e.g. diabetic or alcohol-related, sciatica, neuralgia
• Deficiency of vitamins B1, B6 and B12
• Supportive treatment in back and neck pain with nerve involvement
• Injection: severe deficiency, as directed by a doctor

Adults: 1 tablet once to three times daily, or as directed (commonly 100 mg B1 + 200 mg B6 + 200 mcg B12 per tablet).

Injection: 1 ampoule IM daily to 2–3 times weekly, as prescribed.

• Take after meals.
• Long-term high-dose use (B6) should be supervised.

• Allergy to any of the vitamins (especially cobalt/cobalamin)
• Leber's disease (hereditary optic nerve atrophy) — cyanocobalamin
• Use of levodopa alone

Usually well tolerated.

• Occasional nausea, stomach upset, diarrhoea.
• Red/pink or dark urine colour is possible.
• Rare: allergic reactions, acne-like rash, itching (more with injections).
• Prolonged high-dose B6 (over 100–200 mg/day for months) can cause nerve damage (numbness).

• Do not exceed the prescribed dose for long periods.
• B12 can mask folate deficiency in megaloblastic anaemia — proper diagnosis needed.
• Injections: rare severe allergic reactions.

High-dose combinations are not recommended in pregnancy and breastfeeding unless prescribed; standard-dose B vitamins are safe.

• Levodopa (pyridoxine reduces effect unless with carbidopa)
• Isoniazid, penicillamine, oral contraceptives (increase B6 needs)
• Metformin, PPIs, colchicine (reduce B12 absorption)

Low toxicity; long-term B6 excess causes neuropathy.

Store below 25–30°C, protected from light and moisture.