Prostanil 400 mcg Capsule

Alpha-1 blocker for:

• Urinary symptoms of benign prostatic hyperplasia (BPH): weak stream, frequency, urgency, night-time urination
• Helping passage of ureteric (kidney) stones (off-label, on doctor's advice)

Adult men: 0.4 mg once daily, about 30 minutes after the same meal each day (usually breakfast).

• Swallow whole; do not crush or chew.
• Effect starts within 1–2 weeks.
• Ureteric stones: 0.4 mg daily for up to 4 weeks (doctor's advice).

• Allergy to tamsulosin
• History of fainting on standing (orthostatic hypotension)
• Severe liver impairment
• Use with strong CYP3A4 inhibitors (ketoconazole) in poor metabolisers

Common: dizziness, abnormal ejaculation (reduced or absent semen — harmless), headache.

Less common: dizziness on standing, palpitations, runny/blocked nose, weakness, nausea, constipation or diarrhoea.

Rare but serious: fainting, priapism (painful erection over 4 hours — emergency), severe skin reactions, angioedema; floppy iris syndrome during cataract surgery.

• Stand up slowly; take the first dose carefully (dizziness).
• Tell the eye surgeon before cataract or glaucoma surgery.
• Prostate cancer should be excluded before treating urinary symptoms.
• Severe kidney impairment: caution.

Not indicated for women.

• Other alpha-blockers (doxazosin, prazosin) — do not combine
• PDE-5 inhibitors (sildenafil, tadalafil), other antihypertensives (low blood pressure)
• Ketoconazole, ritonavir, clarithromycin, paroxetine (raise levels)

Low blood pressure, fast heartbeat, fainting. Lie down; seek medical care.

Store below 30°C.