Replet Tablet

Dual antiplatelet therapy (one tablet/capsule) for patients already taking both medicines:

• Acute coronary syndrome (unstable angina, heart attack)
• After coronary stent insertion
• Prevention of further events in high-risk vascular disease, as prescribed

Adults: one tablet/capsule (clopidogrel 75 mg + aspirin 75–100 mg) once daily, with or after food.

• Usually started after loading doses of each medicine given separately.
• Duration (often 6–12 months after a stent) is decided by the cardiologist.
• Do not stop without your cardiologist's advice (risk of stent thrombosis and heart attack).
• Not for children under 16.

• Active bleeding (peptic ulcer, brain haemorrhage), bleeding disorders
• Severe liver or kidney impairment
• Allergy to aspirin/NSAIDs (asthma, hives) or clopidogrel
• Last trimester of pregnancy
• Children under 16 (aspirin — Reye's syndrome)

Common: bruising, nosebleeds, bleeding gums, indigestion, heartburn, abdominal pain, diarrhoea.

Less common: stomach/intestinal bleeding (black stools), blood in urine, rash, headache, dizziness.

Rare but serious: major bleeding including in the brain, TTP (fever, purple spots, confusion — emergency), severe allergic reactions, low blood counts, worsening asthma.

• A PPI (pantoprazole preferred) is often added to protect the stomach.
• Report black stools, vomiting blood, severe headache or unusual bleeding immediately.
• Tell surgeons/dentists before procedures; stopping must be planned with the cardiologist.
• Elderly, low body weight, kidney disease: higher bleeding risk.

Avoid in pregnancy unless clearly needed; contraindicated in the last trimester. Avoid breastfeeding during treatment.

• Omeprazole/esomeprazole (reduce clopidogrel effect — use pantoprazole)
• NSAIDs including ibuprofen, anticoagulants (warfarin, rivaroxaban, heparin), SSRIs, steroids (bleeding)
• Methotrexate (toxicity)
• Repaglinide (avoid)
• Fluconazole, fluvoxamine (reduce clopidogrel activation)
• Alcohol (stomach bleeding)

Bleeding; aspirin overdose causes ringing in ears, fast breathing, confusion. Emergency care.

Store below 30°C, dry.