Repran 1 mg Tablet

Short-acting insulin secretagogue (meglitinide) for type 2 diabetes, with diet and exercise — alone or with metformin; useful when meal times are irregular.

Adults: start 0.5 mg (or 1–2 mg if switching from another tablet) within 15 minutes before each main meal (up to 30 minutes before).

• Adjust every 1–2 weeks; up to 4 mg per meal; maximum 16 mg daily.
• Skip a meal — skip the dose; add a meal — add a dose.
• Elderly and kidney impairment: start low.

• Type 1 diabetes, diabetic ketoacidosis
• Severe liver impairment
• Use with gemfibrozil or clopidogrel (severe hypoglycaemia)
• Allergy to repaglinide

Common: low blood sugar (shaking, sweating, hunger, confusion), abdominal pain, diarrhoea.

Less common: nausea, vomiting, constipation, visual disturbance (early in treatment), weight gain.

Rare: liver enzyme rise, allergic skin reactions.

• Learn hypoglycaemia symptoms and carry sugar/glucose.
• Alcohol, missed meals, heavy exercise increase hypoglycaemia risk.
• Monitor blood sugar regularly.

Not recommended in pregnancy (insulin preferred) or while breastfeeding.

• Gemfibrozil, clopidogrel (contraindicated/avoid — greatly raise levels)
• Clarithromycin, itraconazole, ketoconazole, ciclosporin, trimethoprim (raise levels — low sugar)
• Rifampicin, carbamazepine (reduce effect)
• Beta-blockers (mask low-sugar symptoms); alcohol

Severe hypoglycaemia: give sugar by mouth if conscious; emergency glucose if unconscious.

Store below 30°C.