Ryth 300 mg Tablet

Macrolide antibiotic for:

• Throat infections (tonsillitis, pharyngitis), sinusitis, otitis media
• Bronchitis, community-acquired pneumonia (mild), atypical pneumonia
• Skin and soft tissue infections
• Non-gonococcal urethritis (chlamydia)

Adults: 150 mg twice daily or 300 mg once daily, at least 15 minutes before meals, usually for 5–10 days.

Children: 5–8 mg/kg/day in 2 divided doses (e.g. 50 mg twice daily for 12–23 kg; 100 mg twice daily for 24–40 kg).

• Severe liver impairment: 150 mg once daily.
• Complete the full course.

• Allergy to macrolides
• Use with ergotamine/dihydroergotamine, cisapride, pimozide, astemizole/terfenadine

Common: nausea, abdominal pain, diarrhoea, indigestion.

Less common: headache, dizziness, rash, raised liver enzymes.

Rare: QT prolongation, hepatitis, severe allergy, C. difficile diarrhoea.

• QT prolongation, low potassium/magnesium, heart rhythm disorders: caution.
• Liver impairment: reduce dose.
• Myasthenia gravis may worsen.

Limited data; use in pregnancy only if needed. Very small amounts in breast milk — usually acceptable for short courses.

• Ergot alkaloids (ergotism — contraindicated)
• QT-prolonging drugs (arrhythmia)
• Theophylline, digoxin, ciclosporin, midazolam, warfarin (levels/effects may rise — monitor)
• Statins (simvastatin) — myopathy risk

Nausea, vomiting, diarrhoea. Supportive care; check ECG.

Store below 30°C, protected from moisture.