S-Pirin 100 mg Tablet

Antiplatelet (low dose) and pain/fever reliever (higher dose):

Low dose (75–150 mg):

• Prevention of heart attack and stroke in people with heart disease, after a heart attack, stroke/TIA, stents or bypass surgery
• Acute heart attack and unstable angina (with other treatment)
• Pre-eclampsia prevention in high-risk pregnancy (on specialist advice)

Higher dose (300–900 mg): headache, toothache, period pain, fever, muscle pain in adults; Kawasaki disease (specialist)

Cardiovascular prevention: 75–100 mg once daily after food (dispersible or enteric-coated).

Suspected heart attack: 300 mg chewed immediately (if not allergic), then 75 mg daily.

After ischaemic stroke: 300 mg daily for 2 weeks, then long-term antiplatelet as advised.

Pain/fever (adults and over 16 years): 300–900 mg every 4–6 hours as needed; maximum 4 g daily.

• Take with or after food; swallow enteric-coated tablets whole.
• Do not give to children under 16 years (risk of Reye's syndrome) except on specialist advice.

• Children under 16 (unless specialist-directed)
• Allergy to aspirin or NSAIDs (asthma, hives, swelling)
• Active peptic ulcer, history of recurrent ulcers or bleeding
• Bleeding disorders (haemophilia), severe thrombocytopenia
• Severe liver, kidney or heart failure
• Gout (high dose)
• Last trimester of pregnancy at doses above 100 mg/day

Common: indigestion, heartburn, nausea, easy bruising, nosebleeds, prolonged bleeding from cuts.

Less common: stomach ulcer, rash, worsening of asthma in sensitive people.

Rare but serious: stomach or intestinal bleeding (black stools, vomiting blood), bleeding in the brain, severe allergic reactions, Reye's syndrome in children; ringing in ears with high doses.

• Tell the dentist/surgeon before procedures; do not stop low-dose aspirin after stents or heart attack without your cardiologist's advice.
• Asthma, uncontrolled high blood pressure, G6PD deficiency, elderly: caution.
• A PPI may be added in people at risk of stomach bleeding.

Low dose (75–150 mg) may be prescribed in pregnancy for pre-eclampsia prevention. Avoid analgesic doses, especially in the last trimester. Avoid regular analgesic doses while breastfeeding; occasional low-dose use is acceptable.

• Anticoagulants (warfarin, rivaroxaban), clopidogrel, ticagrelor, SSRIs (bleeding — use only together if prescribed)
• Ibuprofen and other NSAIDs (stomach bleeding; ibuprofen may block aspirin's heart protection — take aspirin at least 30 minutes before ibuprofen)
• Corticosteroids (ulcers)
• Methotrexate (toxicity)
• ACE inhibitors, diuretics (reduced effect at high doses)
• Alcohol (stomach bleeding)

Ringing in ears, nausea, vomiting, fast breathing, confusion, fever, seizures — medical emergency (salicylate poisoning), especially in children.

Store below 25–30°C, dry. Discard tablets that smell strongly of vinegar.