Sofa 250 mg Capsule

Penicillinase-resistant penicillin for infections caused by Staphylococcus and Streptococcus:

• Skin and soft-tissue infections: boils, abscesses, impetigo, cellulitis, infected wounds, infected eczema
• Ear infection (otitis externa)
• Bone and joint infections (osteomyelitis, septic arthritis)
• Pneumonia, endocarditis and septicaemia caused by sensitive staphylococci (injection)

Adults: 250–500 mg every 6 hours; up to 1 g every 6 hours in severe infections.

Injection: 250 mg–2 g every 6 hours IM/IV (higher doses in endocarditis/osteomyelitis).

Children: 2–10 years: half the adult dose; under 2 years: quarter of the adult dose; or 12.5–25 mg/kg every 6 hours, as prescribed.

• Take on an empty stomach: 1 hour before or 2 hours after food.
• Complete the full course.

• Allergy to penicillins
• Previous jaundice or liver problems caused by flucloxacillin

Common: nausea, diarrhoea, indigestion.

Less common: rash, hives, itching.

Rare but serious: liver inflammation and cholestatic jaundice (may appear up to 2 months after stopping, more common over 50 years and with courses over 14 days), severe allergy, C. difficile colitis, blood disorders, kidney inflammation.

• Report yellow eyes/skin, dark urine or pale stools even after finishing the course.
• Use with care in liver disease, the elderly and long courses (liver tests advised).
• Tell your doctor about any penicillin allergy.

Considered safe in pregnancy. Small amounts pass into breast milk — generally compatible.

• Methotrexate (toxicity increases)
• Paracetamol (long-term combination: risk of high anion gap metabolic acidosis in severely ill patients)
• Probenecid (raises levels)
• Warfarin (INR changes)
• Oral contraceptives (effect may fall during diarrhoea)

Nausea, vomiting, diarrhoea; seizures possible at very high doses, especially in kidney failure.

Store below 30°C, dry. Reconstituted syrup: refrigerate and use within 7 days.