Spardon 200 mg Tablet

Fluoroquinolone antibiotic for:

• Community-acquired pneumonia and acute flare-ups of chronic bronchitis
• Typhoid fever (in some guidelines)
• Other infections caused by sensitive organisms when alternatives are unsuitable

Adults: 400 mg on day 1, then 200 mg once daily for a total of 10 days (or as prescribed).

• Kidney impairment (CrCl < 50): 400 mg day 1, then 200 mg every 48 hours.
• With or without food; avoid antacids/iron/zinc within 4 hours.
• Not for children under 18.

• Allergy to quinolones
• QT prolongation (congenital or acquired), use with QT-prolonging drugs, low potassium/magnesium
• History of tendon disorders with quinolones
• Children, pregnancy, breastfeeding
• Epilepsy

Common: sun sensitivity/phototoxicity (severe sunburn-like reactions), nausea, diarrhoea, headache, insomnia, dizziness.

Serious: QT prolongation and dangerous arrhythmias, tendon inflammation and rupture, peripheral neuropathy, seizures, mood changes, aortic aneurysm risk, low/high blood sugar, C. difficile colitis.

• Avoid sunlight and UV exposure during treatment and for several days after.
• Stop at the first sign of tendon pain, tingling, palpitations or mood change.
• Elderly, steroid users, transplant recipients: tendon risk higher.
• Diabetes: monitor sugar.

Contraindicated in pregnancy and breastfeeding.

• QT-prolonging drugs (amiodarone, sotalol, macrolides, antipsychotics, tricyclics, cisapride) — contraindicated
• Antacids, sucralfate, iron, zinc, calcium (reduce absorption — 4 hours apart)
• NSAIDs (seizure risk), steroids (tendon rupture)
• Warfarin (raised INR); diabetes medicines

Arrhythmias, seizures. Emergency care with ECG monitoring.

Store below 30°C, protected from light.