Topup 10 mg Tablet

PDE-5 inhibitor for:

• Erectile dysfunction
• Benign prostatic hyperplasia (BPH) urinary symptoms, with or without erectile dysfunction
• Pulmonary arterial hypertension (specialist use)

Erectile dysfunction (as needed): 10 mg taken at least 30 minutes before sexual activity; may be adjusted to 5–20 mg; not more than once a day. Effect lasts up to 36 hours.

Daily use (ED or BPH): 2.5–5 mg once daily at the same time.

Pulmonary hypertension: 40 mg once daily (specialist).

• Kidney or liver impairment: lower doses.
• Sexual stimulation is needed for it to work.

• Use with nitrates (glyceryl trinitrate, isosorbide) or riociguat — dangerous drop in blood pressure
• Recent heart attack (within 90 days), unstable angina, heart failure in which sexual activity is unsafe
• Uncontrolled low or high blood pressure, recent stroke
• Loss of vision from NAION
• Children and women (for ED)

Common: headache, indigestion, back and muscle pain, flushing, stuffy nose, dizziness.

Less common: palpitations, blurred vision, eye pain, low blood pressure.

Rare but serious: prolonged painful erection over 4 hours (emergency), sudden loss of vision or hearing, chest pain, severe allergy.

• Check heart fitness for sexual activity before use.
• Avoid heavy alcohol (low blood pressure).
• Seek urgent help for an erection lasting over 4 hours or sudden vision loss.
• Deformity of the penis, sickle-cell disease, leukaemia, myeloma: caution.

Not indicated for women for ED. For pulmonary hypertension in pregnancy, specialist decision.

• Nitrates, riociguat (contraindicated)
• Alpha-blockers (doxazosin, tamsulosin) and other blood-pressure drugs (low BP)
• Ketoconazole, itraconazole, ritonavir, clarithromycin, grapefruit (raise levels — lower dose)
• Rifampicin (reduces effect)

Exaggerated side effects: headache, low blood pressure, back pain. Supportive care.

Store below 30°C.