Trum 3-1 gm Injection

Third-generation cephalosporin injection (active against Pseudomonas) for serious hospital infections:

• Pneumonia including hospital-acquired and in cystic fibrosis
• Complicated urinary tract and kidney infections
• Septicaemia, meningitis
• Abdominal, bone, joint, skin infections
• Infections in patients with low white cell counts (febrile neutropenia)

Adults: 1–2 g IV/IM every 8–12 hours; severe infections 2 g every 8 hours (maximum 6 g/day).

• Urinary infection: 500 mg–1 g every 12 hours.

Children: 30–50 mg/kg every 8 hours (maximum 6 g/day); neonates 25–30 mg/kg every 12 hours.

Kidney impairment: dose reduction required.

• Given only by health professionals; reconstitute with water for injection or lidocaine (IM).

• Allergy to cephalosporins
• Severe immediate allergy (anaphylaxis) to penicillins or other beta-lactams
• Lidocaine-diluted IM injection: not for IV use, nor in lidocaine allergy

Common: pain or inflammation at the injection site, diarrhoea, rash, raised liver enzymes, raised eosinophils.

Rare but serious: anaphylaxis, C. difficile colitis, severe skin reactions, seizures or confusion (especially with kidney impairment and high doses), low blood counts.

• Ask about beta-lactam allergy.
• Adjust dose in kidney impairment to avoid nerve toxicity.
• Prolonged use may cause resistant infections.

Considered safe in pregnancy when needed. Small amounts pass into milk; generally compatible with breastfeeding.

• Aminoglycosides, furosemide (kidney toxicity — monitor)
• Chloramphenicol (antagonism)
• Oral contraceptives (may reduce effect)

Seizures, encephalopathy, especially in kidney failure. Supportive care; haemodialysis removes it.

Store powder below 25°C, protected from light. Use reconstituted solution promptly (as per leaflet).