Xelevo 500 mg Tablet

Fluoroquinolone antibiotic for:

• Community-acquired pneumonia and acute bacterial sinusitis / exacerbation of chronic bronchitis (when other antibiotics are unsuitable)
• Complicated urinary tract and kidney infections, chronic prostatitis
• Skin and soft-tissue infections
• Typhoid fever (where sensitive)
• Tuberculosis (drug-resistant, as part of combination therapy)
• Inhalational anthrax, plague
• Eye drops: bacterial conjunctivitis

Adults: 250–750 mg once daily depending on infection:

• Pneumonia: 500 mg once or twice daily (or 750 mg once daily) for 7–14 days.
• Sinusitis / bronchitis: 500 mg once daily for 5–10 days.
• Complicated UTI: 250–750 mg once daily for 5–10 days; prostatitis 500 mg daily for 28 days.

IV: same doses by slow infusion.

Eye drops: 1–2 drops every 2 hours while awake on days 1–2, then 4 times daily.

• Not routinely used in children.
• Take with water; separate from antacids, iron, zinc, calcium and dairy by at least 2 hours.
• Reduce the dose in kidney impairment.

• Allergy to levofloxacin or other quinolones
• Epilepsy
• History of tendon problems with quinolones
• Children and growing adolescents (except special situations)
• Pregnancy and breastfeeding

Common: nausea, diarrhoea, headache, dizziness, sleep problems, raised liver enzymes.

Rare but serious: tendon inflammation or rupture, nerve damage, mood or psychiatric changes, seizures, QT prolongation, blood-sugar changes, aortic aneurysm, sun sensitivity, severe allergy, C. difficile colitis, liver damage.

• Stop at the first sign of tendon pain, tingling/numbness, or mood changes.
• Higher risks in the elderly, with steroids, after transplant.
• Use with care in diabetes, myasthenia gravis, heart-rhythm problems.
• Avoid strong sunlight and UV lamps.

Contraindicated in pregnancy and while breastfeeding.

• Antacids, iron, zinc, sucralfate, calcium (reduce absorption)
• QT-prolonging drugs
• Warfarin (bleeding risk)
• NSAIDs (seizure risk)
• Corticosteroids (tendon rupture risk)
• Diabetes medicines (low or high blood sugar)

Confusion, dizziness, seizures, QT prolongation, nausea. Seek emergency care; ECG monitoring.

Store below 30°C, protected from light. Discard eye drops 4 weeks after opening.