Xytrex 10 mg Tablet

Atypical antipsychotic for:

• Schizophrenia
• Bipolar disorder: manic episodes and prevention of recurrence
• With fluoxetine: treatment-resistant/bipolar depression (specialist)
• Short-term IM: agitation in schizophrenia or mania (hospital)
• Low dose: prevention of chemotherapy-induced nausea (specialist)

Schizophrenia: 10 mg once daily; range 5–20 mg daily.

Mania: 15 mg once daily (10 mg with other mood stabilisers); range 5–20 mg.

Relapse prevention (bipolar): 10 mg daily (5–20 mg).

Elderly, women non-smokers, liver impairment: consider starting at 5 mg.

• Once daily, with or without food; orodispersible tablets dissolve on the tongue.
• Not recommended under 18 years.

• Allergy to olanzapine
• Narrow-angle glaucoma (risk)

Very common: weight gain, drowsiness, raised prolactin, raised cholesterol/triglycerides, dizziness on standing.

Common: increased appetite, raised blood sugar/diabetes, dry mouth, constipation, swelling, restlessness, tremor, raised liver enzymes, tiredness.

Rare but serious: neuroleptic malignant syndrome, tardive dyskinesia, seizures, low white cells, blood clots, DRESS (severe skin reaction), pancreatitis, increased stroke and death risk in elderly with dementia; post-injection delirium syndrome with long-acting injection.

• Monitor weight, blood sugar and lipids before starting and regularly.
• Avoid in elderly with dementia-related psychosis.
• Seizure history, prostate enlargement, paralytic ileus, liver disease: caution.
• May impair driving; avoid alcohol.

Use in pregnancy only if benefit outweighs risk (monitor for gestational diabetes; newborn may have withdrawal/movement symptoms). Passes into milk — specialist decision.

• Smoking and carbamazepine reduce levels (stopping smoking raises them)
• Fluvoxamine, ciprofloxacin raise levels
• Alcohol, benzodiazepines (sedation; IM olanzapine with IM benzodiazepines — avoid)
• Levodopa, dopamine agonists (opposing effect)
• Antihypertensives (low blood pressure)

Drowsiness, agitation, slurred speech, fast heartbeat, movement disorders, reduced consciousness, low blood pressure, seizures. Emergency care.

Store below 30°C, protected from light and moisture.