Thiovit 100 mg Tablet

Vitamin B1 for:

• Treatment and prevention of thiamine deficiency (beriberi)
• Wernicke's encephalopathy and its prevention in alcohol dependence, malnutrition, prolonged vomiting (hyperemesis), after bariatric surgery
• Peripheral neuritis due to deficiency
• Nutritional supplementation

Mild deficiency / prevention (oral): 10–25 mg daily; in alcohol dependence 100 mg two to three times daily (oral absorption is limited).

Severe deficiency: 200–300 mg daily in divided doses.

Wernicke's encephalopathy (hospital): high-dose IV thiamine (e.g. 200–500 mg three times daily for several days), given before glucose, then oral maintenance.

Children (deficiency): 10–50 mg daily in divided doses.

• Injections only by health professionals.

• Allergy to thiamine (rare; mainly with injections)

Oral: very well tolerated; rarely stomach upset.

Injection: pain at the injection site; rarely severe allergic reactions/anaphylaxis (especially with fast IV injection), so it should be given slowly with resuscitation facilities.

• In malnourished or alcohol-dependent patients, give thiamine before glucose-containing fluids to avoid precipitating Wernicke's encephalopathy.
• Oral thiamine is not a substitute for IV treatment in suspected Wernicke's encephalopathy.

Safe in pregnancy and breastfeeding at recommended doses; used in hyperemesis gravidarum.

• Alcohol reduces absorption
• Loop diuretics (furosemide) may increase thiamine loss with long-term use
• No significant harmful interactions

Excess is excreted in urine; oral overdose is unlikely to be harmful. Large IV doses may cause allergic reactions.

Store below 30°C, protected from light.